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filingDate 2021-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113750067-B
titleOfInvention A kind of preparation technology of levofloxacin tablet
abstract The present invention proposes a preparation process of levofloxacin tablets, comprising the following steps: (1) pulverizing levofloxacin, microcrystalline cellulose and hydroxypropyl cellulose respectively; Coating liquid; (3) add hydroxypropyl cellulose pulverization, starch nanocrystal and microcrystalline cellulose pulverization to levofloxacin pulverization, warm air setting, granulation, drying, adding magnesium stearate, coating liquid spraying processing and tableting to obtain tablet cores; (4) preheating the tablet cores and adding the remaining coating liquid to obtain levofloxacin tablets. The quality of the levofloxacin tablets prepared by the invention complies with the standards of the Chinese Pharmacopoeia, the in vitro dissolution rate is good, and the component release rate is gentle, which is conducive to improving the bioavailability, and the product can maintain a good appearance, moderate hardness and main drug content under long-term storage. The loss is small, the product quality is stable, and it is suitable for large-scale industrial production.
priorityDate 2021-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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