| abstract |
The present invention provides a micro-nano carrier based on starch-curcumin conjugate and application thereof. The repeating structural unit of the starch-curcumin conjugate has the structure shown in the following formula, The numbers of R 1 , R 2 and R 3 are all integers between 0 and 5, the numbers of R 4 and R 5 are integers between 1 and 6, and the numbers of R 1 to R 5 are all integers between 1 and 6. The sum of the number of groups is equal to 6; the distribution of R 1 ~R 5 groups on the ring structure is random distribution; X is an integer between 1 and 8; n is the number of repeating units in the polymer structure, It is an integer between 10 and 100000. The starch-curcumin conjugate is used to prepare drug-loaded micro-nano carriers, which can contain drugs with different physical and chemical properties, and curcumin itself has various pharmacological activities such as anticancer, anti-inflammatory, and antibacterial. Therefore, the micro-nanocarriers based on starch-curcumin conjugates can be used as novel drug delivery systems for the treatment of various diseases. |