| abstract |
The invention discloses the application of soluble dietary fiber in kelp in preparing medicine and functional food for improving ulcerative colitis. The invention extracts soluble dietary fiber from kelp residue, and constructs a mouse model of ulcerative colitis, which verifies for the first time that soluble dietary fiber can inhibit the weight loss and disease activity index of mice; inhibit colon lesions and shortening; to balance the levels of inflammatory factors in the body; up-regulate the expression of tight junction proteins in the gut; restore the diversity and abundance of intestinal flora; increase the production of short-chain fatty acids such as butyrate, acetate, and propionate. The soluble dietary fiber in the kelp belongs to a natural active substance, is safe and has no toxic and side effects, can treat gastrointestinal diseases such as enteritis based on dietary intervention, avoids the adverse reactions of traditional drug treatment, and has a good application prospect. |