http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113730332-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_489f9d7465289f4d9171ae039810fb25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_65682d3e437c225d79b93953b4b26392 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2021-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d382a191ea3fd07605844df33221368 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84ec444a6efe79c5152ac11f7843385f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d50fbabb78be5fbdaddc36f54472dbe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82dd2c2bed5fd9f45b7b09a5ba274f36 |
| publicationDate | 2021-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113730332-A |
| titleOfInvention | A kind of accelerator targeting tumor surface collagen and preparation method and application thereof |
| abstract | The invention discloses an accelerator targeting tumor surface collagen and a preparation method and application thereof. Polyethylene glycol, EDC and NHS are mixed with dimethyl sulfoxide to obtain solution B, and then solution B is added dropwise to the solution. There is a solution A1 of fluorinated chitosan or a solution A2 of chitosan, corresponding to obtain PFCS or PCS, dropwise addition of perfluoroheptanoic acid solution to the PCS to modify to obtain PFCS, to the polyethylene obtained by the above two schemes. The diol-modified fluorinated chitosan is added with excess glutaraldehyde and stirred in the dark to obtain the drug transepithelial absorption enhancer targeting collagen on the tumor surface, and the target tumor surface prepared by this method The aldehyde group on the surface of the promoter of collagen can provide aldehyde-ammonia "Schiff base" selective adhesion to the collagen amino group at the tumor site, while the modified fluorinated chitosan structure can help regulate bladder epithelial tight junctions, thereby opening the upper epithelium. Epithelial drug barrier, thereby enhancing the penetration of therapeutic drugs to bladder tumors, can be used for perfusion therapy of bladder cancer. |
| priorityDate | 2021-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.