http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113717090-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-16 |
| filingDate | 2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113717090-B |
| titleOfInvention | Trifluoromethyl-containing all-carbon quaternary carbon center indole acetonitrile compound and preparation method and application thereof |
| abstract | The invention relates to the technical field of organic synthesis, and particularly relates to a trifluoromethyl-containing all-carbon quaternary carbon center indole acetonitrile compound and a preparation method and application thereof. The preparation method of the compound comprises the steps of taking trifluoromethyl indoles alcohol compound and trimethylsilyl cyanide as raw materials, and heating and reacting in a solvent under the catalytic action of a Lewis acid catalyst to obtain the trifluoromethyl all-carbon quaternary carbon center indole acetonitrile compound. The synthetic method of the trifluoromethyl all-carbon quaternary carbon center-containing indole acetonitrile compound takes the simple and easily obtained trifluoromethyl indole alcohol compound and the trimethyl cyano silane as raw materials, takes the tris (pentafluorophenyl) borane as a catalyst, does not need to use a metal catalyst and a virulent inorganic cyanide as a cyanogen source, and has the advantages of mild reaction conditions, simple operation, high yield, wide range of reaction substrates and the like. |
| priorityDate | 2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.