| abstract |
The invention provides a chimeric membrane vesicle and a preparation method and application thereof, relating to the technical field of biological medicine. The raw materials for preparing the Neu-Ex comprise hucMSC-Ex and Neu-NVs, and the hucMSC-Ex and the Neu-NVs are ultrasonically mixed and then extruded to obtain the Neu-Ex. The Neu-Ex can be stored for a long time at the temperature of minus 80 ℃ after being subpackaged, is easy to store and use, can be directly used for preventing and treating the acute kidney injury induced by the cisplatin, and has obvious effect; and the Neu-Ex is counted according to particles, the dosage is convenient to master, and the Neu-Ex can be used for preparing a medicinal preparation for preventing and treating acute kidney injury. |