| abstract |
The invention discloses a novel tretinoin nanoemulsion adjuvant for efficiently enhancing humoral immune response and mucosal immune response, and a preparation method and application thereof. The tretinoin nanoemulsion adjuvant provided by the invention can be co-delivered with various antigens (mode antigen OVA, staphylococcus aureus recombinant protein antigen and new coronavirus recombinant protein antigen) respectively, can enhance the immune response level of vaccine antigens after injection immunization, has a good immune protection effect, can induce systemic humoral immune response, can efficiently activate the immune response of mucosal parts (intestinal mucosa, vaginal mucosa, pulmonary mucosa, gastric mucosa and nasal mucosa), and has great market application value and wide application prospect. |