Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97bd68cb0a98913a5940c708e7ce1679 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2440-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-485 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 |
filingDate |
2020-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6738bc402398892843664ef16f5def24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_013bffc8396ff6945b10fce5439d1300 |
publicationDate |
2021-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-113710700-A |
titleOfInvention |
Threonine 166 and serine 189 of the Rubicon RUN domain as LRRK2 kinase inhibitory targets |
abstract |
Methods of using antibodies to detect phosphorylation of threonine 166 and/or serine 189 of Rubicon protein to identify subjects with diseases associated with leucine-rich repeat kinase 2 (LRRK2), such as Parkinson's disease. Also disclosed are methods of using inhibitors to block the interaction of LRRK2 with threonine 166 and/or serine 189 of the Rubicon protein. |
priorityDate |
2019-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |