| abstract |
The solubility and bioequivalence of meloxicam can be improved by preparing a composition of meloxicam co-crystals and reducing (e.g., "nanocrystallizing") the particle size of the co-crystals. The pharmaceutical composition with improved solubility pharmacokinetic properties can be made into oral solid dosage forms by granulating and mixing the co-crystal and extra-granular excipients. Due to the improved properties of the oral dosage form of meloxicam, the composition is useful in the treatment of pain, including acute pain. |