| abstract |
The invention discloses a synthesis method of a polysubstituted 3-sulfonamide quinoline compound, which comprises the steps of forming an alpha-imine gold carbene intermediate by attacking alkynyl by gold catalytic azide groups; 1,2-N migration is initiated under the action of an alpha-imine intermediate, so that a multi-substituted 3-sulfonamide quinoline compound is formed. The synthetic method has the advantages of high efficiency, strong universality on substrates and the like. |