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filingDate 2021-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113679890-B
titleOfInvention A kind of heart valve leaflet and preparation method thereof
abstract The invention discloses a heart valve leaflet and a preparation method thereof. The heart valve leaflet has a three-layer structure, and the three-layer structure is a fiber layer, a sponge layer and a ventricular layer in sequence; the preparation material of the fiber layer includes a polymer and gelatin or collagen; the preparation materials of the sponge layer include polymers and polysaccharides; the preparation materials of the ventricular layer include polymers and silk fibroin; the polymers are selected from PLCL, PLA, PLGA, PCL and at least one of PU; the heart valve leaflet is in composition, and each layer component is similar to the natural heart valve component; structurally, the three-layer structure is obvious, similar to the three-layer structure of the natural valve leaflet; functionally It has suitable mechanical properties, can promote cell proliferation and adhesion, maintain cell viability, and can down-regulate the expression of calcification-related genes. Microenvironment.
priorityDate 2021-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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