| abstract |
The invention relates to the technical field of medicine, in particular to the new use of cephalosporins in the preparation of medicaments for the treatment of diabetes. Glucose metabolism in mice, improve insulin sensitivity, improve insulin resistance, reduce blood sugar in type 2 diabetic mice, and its hypoglycemic effect is 12.5 times that of metformin; reduce urine protein, urine creatinine and blood urea nitrogen in type 2 diabetic mice It shows that cephalosporins can protect the renal function of diabetic mice and treat nephropathy caused by diabetes; reduce the content of triglyceride, low-density lipoprotein cholesterol and total cholesterol in type 2 diabetic mice, regulate blood lipid levels, and improve diabetes The lipid metabolism in mice shows that cephalosporins can treat cardiovascular complications of diabetes and can be applied in clinical practice. |