http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113667006-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6967bba8150e0b546153ebb0fbc0eec9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10 |
| filingDate | 2020-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ad270b0ad1ac035ea2ed9c045d4aac6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a2722b020d7a066dd51f076606e10a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8bf2eab6665a673eb6c825e57433a5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_267524d0b272ac26ad9b2344c31a6234 |
| publicationDate | 2021-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113667006-A |
| titleOfInvention | A kind of preparation method of semaglutide dipeptide side chain |
| abstract | The invention belongs to the field of medicine and chemical industry, and particularly relates to a preparation method of a semaglutide dipeptide side chain. The preparation method of the present invention is that Fmoc-His(Trt)-OH and thionyl chloride are heated to reflux, and the obtained product is further combined with 2-aminoisobutyric acid to obtain the important side chain Fmoc-His-Aib-OH of semaglutide. The method for synthesizing the side chain of semaglutide dipeptide provided by the invention simplifies the operation steps, that is, in the first step, the Trt can be removed, and the carboxylic acid can be prepared into an acid chloride, and the target compound can be obtained by only two steps of reaction. At the same time, the next-step acylation reaction rate is fast and the yield is high, which is beneficial to the large-scale production of semaglutide and meets the needs of industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115197312-A |
| priorityDate | 2020-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.