| abstract |
The invention discloses the construction of a multifunctional mesoporous iron oxide nanodiagnostic preparation based on magnetic targeting and its application in the preparation of antitumor drugs; the Fe 3 O 4 synthesized by the invention has magnetic targeting, magnetic resonance, optical The functions of acoustic imaging, photothermal imaging and therapy; using PIONs to load pcDNA3.1‑LNC CRYBG3 to obtain PIONs‑pDNA complexes, of which the pcDNA3.1‑LNC CRYBG3 plasmid contains the sequence of LNC CRYBG3, which will be further amplified after entering cells , increased the expression of LNC CRYBG3 in cells, and then exerted its effect of inhibiting tumor cell proliferation. The magnetic targeting-based multifunctional PIONs nano-diagnostic preparation of the present invention has excellent functions of MRI/PA/PTT multimodal imaging, photothermal therapy and gene therapy, and fulfills the needs of tumor multimodal imaging and combined therapy. |