http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113637709-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0625 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0686 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 |
| filingDate | 2021-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2023-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2023-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113637709-B |
| titleOfInvention | Application of KIF5B gene as a target in inhibiting the replication of foot-and-mouth disease virus |
| abstract | First, the present invention finds that by inhibiting or silencing the host KIF5B gene, the replication of FMD virus can be inhibited, which can be used as a target for preparing or screening drugs for inhibiting the replication of FMD virus; secondly, with KIF5B as the target, the present invention designs siRNA, The siRNA can inhibit the replication of the foot-and-mouth disease virus, and can be used to prepare a drug for inhibiting the replication of the foot-and-mouth disease virus; meanwhile, the present invention provides a sgRNA specifically targeting KIF5B, and the sgRNA can target the KIF5B gene, and in combination with CRISPR-Cas9 technology, realizes The KIF5B gene in the host cells was completely knocked out, and the obtained monoclonal cell line had a resistant phenotype to the foot-and-mouth disease virus, which could significantly inhibit the replication of the foot-and-mouth disease virus in the cells. Molecular mechanisms provide research tools and materials. |
| priorityDate | 2021-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 632.