http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113636958-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9767d38a643304fccdb915d4dc7f9624 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-18 |
| filingDate | 2021-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4fd01b919930b25a89766fe5b405718 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4395505edee6360a920601f4f107dd68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff39e6f9b79e5fa7750ed7686bd0cb3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_092c0936c4ab22fc4d5f80b0be221ed8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e24381afecc090c71017f4385a5d121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_279feaca4e9c863531d8f9d10c93e703 |
| publicationDate | 2021-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113636958-A |
| titleOfInvention | A kind of preparation method of 2-methyl-5-nitrophenylguanidine |
| abstract | The invention relates to a preparation method of 2-methyl-5-nitrophenylguanidine, and belongs to the technical field of pharmaceutical intermediate synthesis. In order to solve the problems of high corrosiveness and low yield in the existing reaction, a preparation method of 2-methyl-5-nitrophenylguanidine is provided, the method comprising, in the presence of an acid binding agent, mixing 2-chloro- 4-nitrotoluene and guanidine hydrochloride are subjected to a condensation reaction in an alcohol solvent to obtain the corresponding product 2-methyl-5-nitrophenylguanidine. The invention can realize high efficiency and conversion rate, the product yield can reach more than 90%, and the purity can reach more than 99%. In addition, the reaction conditions are mild, the operation is easier, and the cost is relatively low, which is more favorable for industrial production. |
| priorityDate | 2021-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.