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filingDate 2021-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113633789-B
titleOfInvention A liquid metal nanoprobe integrating photoacoustic imaging and drug encapsulation and preparation method thereof
abstract The invention discloses a liquid metal nano probe integrating photoacoustic imaging and drug encapsulation and a preparation method thereof. In the preparation method, the liquid metal is mixed with the tannic acid aqueous solution and then subjected to ultrasonic treatment, and the upper layer liquid is taken and further purified by gentle centrifugation to remove relatively large particles; then, the pharmaceutical preparation is mixed with the above-mentioned liquid metal nanoparticles, The drug-loaded liquid metal nanoprobe is obtained. The drug-loaded liquid metal nano-probe of the present invention is injected into the tumor in situ to make it evenly distributed in the tumor site. Under laser irradiation, the drug-loaded liquid metal nano-probe will swell and deform, and the drug will be released from the surface of the nano-probe , Photothermal therapy and chemotherapy combined treatment, two-pronged approach to eliminate tumors.
priorityDate 2021-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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