| abstract |
The present invention provides a compound for use in isolating unwanted (eg, associated with autoimmune disease) antibodies in a patient. The compound comprises an inert biopolymer scaffold and at least a first peptide n-mer having the general formula P(-S-P) (n-1) and a first peptide n-mer having the general formula P(-S-P) (n-1) A second peptide n-mer; wherein, independently for each occurrence, P is a peptide with a sequence length of 2-13 amino acids, and S is a non-peptide spacer, wherein, independently for each peptide n-mer, n is An integer of at least 1 where each peptide n-mer is bound to a biopolymer scaffold. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of isolating one or more antibodies present in an individual and methods of suppressing an immune response to treatment with an active agent. |