| abstract |
Antibodies and antigen-binding fragments thereof that specifically recognize and bind to exposed and accessible elastin epitopes in degraded elastic fibers are described. The antibody and/or antigen-binding fragment can be operably linked to a second component that includes a biologically active agent, such as a therapeutic agent and/or an imaging agent. Optionally, the antibody and/or antigen-binding fragment thereof can be attached to the surface of a carrier, such as a particle, for specific binding and delivery of the entrained agent to the degraded elastic fibers. |