| abstract |
Provides a platform for discovery and analysis of therapeutic agents. A method of characterizing candidate reagents, comprising the steps of: (a) providing a library of candidate reagents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate reagents to the solid support, Thereby forming an array of candidate reagents; (c) contacting the array with a screening agent, wherein one or more candidate reagents in the array are reacted with the screening agent; (d) detecting the array to determine at least one in the array A candidate reagent is reacted with a screening agent; (e) nucleic acid tags are sequenced to determine the sequence of tags attached to the candidate agents in the array; and (f) based on the sequence of tags attached to the at least one candidate agent, identifying the the at least one candidate agent in the array that is reactive with the screening agent. |