http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113620789-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b080cef8482590e5409bfa83dc09113c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-26 |
| filingDate | 2021-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8cfa97b5844b43bb2944e7786e77bbc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d564e4ece53a49006d94cd809149b1c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60e1ea4f4179cc05e60866a77362b5e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fafbfcf61863d8c8df6d2cc0cbe276a |
| publicationDate | 2021-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113620789-A |
| titleOfInvention | Chiral alpha-fluoroalkoxy alcohol and preparation method thereof |
| abstract | The invention relates to chiral alpha-fluoroalkoxy alcohol (formula I) and a preparation method thereof. The preparation method related by the invention is a one-pot asymmetric series reaction and comprises the following steps of 1): alpha-bromoacetophenone (formula II) is used as a raw material, fluoroalkyl alcohol (formula III) is used as a solvent and a reaction raw material, 1 equivalent of potassium phosphate is added as a base, and the mixture is reacted for 2 hours at 50 ℃ to generate an intermediate (formula IV); step 2): directly adding a chiral diamine metal complex as a catalyst into a reaction system, using formic acid and triethylamine as hydrogen sources, and carrying out asymmetric transfer hydrogenation under the protection of nitrogen to obtain the chiral alpha-fluoroalkoxy alcohol (shown in a formula I). The method has the advantages of simple and mild reaction conditions, economic steps, economic atoms and the like, is green and has wide substrate application range and high enantioselectivity, and the synthesized chiral alpha-fluoroalkoxy alcohol has wide application prospect in the aspects of medical intermediates and fine chemical raw materials. |
| priorityDate | 2021-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.