| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45ef247660b74a66edc2423527e91d7a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-884 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-88 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-88 |
| filingDate |
2021-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_374598f97a3e660c0459445d76be2e10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9786f32252132633a4c1f453c1af5546
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30be41b6f5a3e47f1f73fb2ae19d5d11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9acc783108b7037a704a50141e1baae1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4835e57b95e8a947ecf879530bb589ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b89aca77a3759e82cdb555230786fe2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_070e0fb0759313de9d288f53e0111adc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_998843f4f930a09dad15a788cbf2f8ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75f296d17ba4d9fb70e26c8ce44ea0c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86d01cd9dcbecb2a49445774019f19d0 |
| publicationDate |
2021-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113607870-A |
| titleOfInvention |
Method for detecting polymer impurities in cefadroxil bulk drug and preparation thereof |
| abstract |
The invention provides a method for detecting polymer impurities in a cefadroxil bulk drug or a preparation thereof, which is based on a reversed-phase high-performance liquid chromatography and comprises the steps of establishing chromatographic conditions and preparing a polymer impurity positioning reference solution; wherein the chromatographic conditions are: stationary phase: octadecylsilane chemically bonded silica, mobile phase: taking 0.02mol/L potassium dihydrogen phosphate solution with the pH value of 4.8-5.2 as a mobile phase A, taking methanol as a mobile phase B, and performing gradient elution; flow rate: 0.9-1.1 ml/min; column temperature: 28-32 ℃; detection wavelength: 220 nm. The method for detecting the polymer impurities in the cefadroxil bulk drug or the preparation thereof can simultaneously detect various polymer impurities, the separation degree of each polymer impurity is good, and the method can eliminate the interference of small molecular impurities in the cefadroxil bulk drug or the preparation thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114166963-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114166963-A |
| priorityDate |
2021-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |