http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113607790-A

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filingDate 2021-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_965561cd9dac975bdab615d0aff4721f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8044376e1be18f840d4a211f394b958e
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publicationDate 2021-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113607790-A
titleOfInvention Construction method of plasma-adjustable Ag @ Au core-shell nano-material reinforced quantum dot electrochemiluminescence sensor
abstract The construction method of the plasma-adjustable Ag @ Au core-shell nano-material reinforced quantum dot electrochemiluminescence sensor comprises the following steps: preparing silver nano seeds, and adjusting the molar ratio of Ag to Au in the synthesis process to obtain the Ag @ Au nuclear shell nano structure material with adjustable plasma; the effective Local Surface Plasmon Resonance (LSPR) -enhanced ECL is obtained by overlapping the ultraviolet absorption spectrum of the Ag @ Au nano material and the ECL emission spectrum of the Quantum Dots (QDs); and (3) constructing an ECL sensor, searching the optimal distance between the Ag @ Au nano material and the QDs, and quantitatively detecting the miRNA-21. The plasma-adjustable Ag @ Au nano material not only effectively solves the problem that the emission spectra of fixed ECL of QDs are difficult to match, but also creatively provides the plasma-adjustable bimetal composite nano material for enhancing ECL signals, is applied to high-sensitivity detection of miRNA-21, and can meet the sensitivity requirement of clinical sample detection.
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