http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113603743-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J63-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 |
| filingDate | 2021-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113603743-B |
| titleOfInvention | A kind of CDDO/Ligustrazinol hybrid compound with combined therapeutic effect and preparation method and use thereof |
| abstract | The invention relates to the technical field of biomedicine, in particular to a class of CDDO/Ligustrazinol hybrid compounds with combined therapeutic action and a preparation method and application thereof, which have the structure shown in the general formula I: The invention adopts the double prodrug strategy, utilizes the LAP response fragment leucine acyl to carry out prodrug protection on the CUK of CDDO drugs, and couples with the active fragment of ligustrazinol to form a CDDO/ligusinol hybrid compound. The present invention utilizes the prodrug to selectively cleave leucine amide bond fragments in the liver inflammatory tissue overexpressed by LAP to release CDDO drugs and ligustrazinol, thereby increasing the concentrations of the two drugs in the liver damaged inflammatory tissue, increasing the The inflammatory treatment effect is reduced, the drug dose is reduced, the toxic and side effects of CDDO drugs are improved, and the drug safety is improved. |
| priorityDate | 2021-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.