| abstract |
The present invention provides a preparation method of 5-halogenated-2[(alkoxycarbonyl)amino]-3-methylbenzoic acid, wherein the preparation method comprises the following steps: under the participation of an organic base, a compound of formula (I) is combined with a compound of formula ( II) The compound is reacted to generate the compound of formula (III); then the compound of formula (III) is reacted with a halogenated reagent to obtain the compound of formula (IV) 5-halogenated-2[(alkoxycarbonyl)amino]-3-methylbenzene formic acid. The reactant raw materials used in the preparation method provided by the invention are cheap and readily available, and have the advantages of good selectivity, few side reactions, high product yield, high product purity, simple and economical process and the like. |