| abstract |
The invention belongs to the technical field of medicine, and in particular relates to a new use of alfuzosin in the preparation of a medicine for treating diabetes and its complications. The present invention finds that alfuzosin participates in the glycation and oxidation process of the body, inhibits cell death, enhances renal function, can effectively reduce blood sugar in diabetic model mice, improves renal function, and reduces triglyceride, low-density lipoprotein cholesterol, and high-density lipid. The related indicators of cardiovascular and cerebrovascular complications such as protein cholesterol can effectively prevent or treat diabetes and its complications, and its effect is 165 times that of the clinical drug metformin, which provides a new method for the preparation of clinical drugs for the treatment of diabetes and its complications. It has good clinical application prospects. |