| abstract |
The invention relates to a long-acting antibacterial and anti-stenosis functional urethral stent and a preparation method thereof. The urethral stent is a tubular structure and consists of inner, middle and outer layers; the middle layer is a fabric tube; and the outer layer is a silk fibroin membrane carrying anti-stenosis drugs; The inner layer is an antibacterial and antifouling coating, which is composed of chitosan-nano silica array, fluff, microvilli and antibacterial drugs; preparation method: after the yarn is made into a fabric tube by a textile molding method, the yarns are respectively placed in the fabric tube. An antibacterial and antifouling coating is prepared on the surface, a silk fibroin film carrying an anti-stenosis drug is prepared on the outer surface, and a long-acting antibacterial and anti-stenosis functional urethral stent is prepared. The method of the invention is simple, the prepared urethral stent has smooth surface and good biocompatibility, not only has excellent radial compression force, circumferential expansion force, resistance to bending and torsion, elastic recovery and other properties, but also has long-term antibacterial properties. And anti-stenosis function, can prevent excessive deposition of urethral collagen tissue, so as to achieve the purpose of treating urethral stricture. |