| abstract |
The invention discloses a preparation method of arbutin solid nano-liposome, comprising the following steps: adopting a multiple emulsion preparation method, preparing cetyl alcohol, caprylic caprylic glyceride, monostearic acid glyceride, ten The polyglycerol monooleate and the tripolyglycerol distearate are mixed and heated to 80-85°C until the oil and the emulsifier are completely melted into an oil phase. Take a certain concentration of arbutin aqueous solution, add it to the oil phase, stir and disperse quickly, then add the oil phase solution of arbutin into deionized water, stir and homogenize, at 60 ~ 65 ℃, use high pressure The arbutin solid nanoliposome is prepared by homogenizing by a homogenizer, and then rapidly cooling after homogenization. The invention obtains arbutin solid nanoliposomes with small particle size, high encapsulation rate and good stability through the preparation process, which can be directly added to whitening cosmetics. |