abstract |
The invention relates to the fields of biomedicine and molecular biology, in particular to a gene, protein, carrier, lentivirus and application with hexokinase 2 inhibitory activity. The gene is the MTSS1 gene, and the encoded MTSS1 protein inhibits the activity of HK2 through competitive binding to mitochondria-binding HK2, down-regulates the level of aerobic glycolysis in breast cancer cells, and then inhibits the invasion and migration of breast cancer cells. Clinically targeting HK2 to inhibit breast cancer metastasis provides a new therapeutic direction and application basis. |