abstract |
The invention relates to the technical field of biology, in particular to a coxsackievirus A6 type strain and application thereof. The invention provides a coxsackie virus A6 strain, wherein the amino acid sequence of the P1 structural protein is shown as SEQ ID NO. 1. The strain has strong cross-neutralization capability in and among genotypes, strong toxicity, high pathogenic and lethal capability on mice, good immunogenicity, high titer and high stability. The strain can be used for immunogenicity evaluation or protective evaluation of a coxsackievirus A6 vaccine, improves the accuracy and repeatability of the immunogenicity evaluation of the vaccine, can also be used for preparing a coxsackievirus infected animal model, and has a good application prospect. |