http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113563258-A

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61
filingDate 2021-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b69119125a2ee3abc7c381d032dbe3e1
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publicationDate 2021-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113563258-A
titleOfInvention A kind of preparation method of 4-bromo-2-(difluoromethyl)-5-methylpyridine
abstract The invention belongs to the technical field of pharmaceutical intermediates, and in particular relates to a preparation method of 4-bromo-2-(difluoromethyl)-5-picoline. In the present invention, compound A is used as a raw material, and 4-bromo-2-(difluoromethyl)-5- is prepared through oxidation reaction, nitration reaction, substitution reaction, reduction reaction, hydrolysis reaction, oxidation reaction and fluorination reaction in sequence. Picoline, the preparation method provides a complete and efficient method for preparing 4-bromo-2-(difluoromethyl)-5-picoline, and the prepared 4-bromo-2-(difluoromethyl)- 5-methylpyridine has high yield and high purity.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115340492-A
priorityDate 2021-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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