| abstract |
The invention discloses a non-viral vector formed based on the covalent assembly of short peptides catalyzed by ruthenium terpyridine, and a preparation method and application thereof. Mix and incubate to obtain DNA-[Ru(bpy) 3 ] 2+ solution; mix DNA-[Ru(bpy) 3 ] 2+ solution, tyrosine-containing targeting peptide solution, and ammonium persulfate solution, and irradiate with white light , the non-viral vector can be obtained after centrifugation; it has the characteristics of simple synthesis, greenness and high efficiency; the non-viral vector can be used in gene delivery or as a targeted drug. |