http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113549096-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_366759959a879950036c4e69dc8fd483 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1088 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-022 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 |
| filingDate | 2021-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b77e75a669cac2da2d2796b9ecbaddf4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_897ab345e06dc8e1cddaeffa8c2153b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_834841399a65ec671193e000f15417d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_001450e9d659f558d33ca83576195eaf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d082a80ae67dd4137320223842ac84d6 |
| publicationDate | 2021-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113549096-A |
| titleOfInvention | Fluorescence probe of alkane bridging A beta inhibitor and preparation method thereof |
| abstract | The invention relates to a fluorescent probe of an alkane spiro A beta inhibitor and a preparation method thereof, and the fluorescent probe comprises the following steps: dissolving an Abeta inhibitor (M) and DCC/DMAP into chloroform according to the molar ratio of 1: 0.1-1/0.1-1, adding 1-1.3 equivalents of (M: M) Linker containing alkane chains, stirring for 1-6 h at 50-100 ℃, removing the solvent by vacuum rotary evaporation at 25-60 ℃, and separating and purifying by adopting a chromatographic column to obtain a solid product M-L n (ii) a NB and M-L n Dissolving the mixture into chloroform according to a molar ratio of 1: 1-3, and adding 0.1-1 equivalent (M: M) of catalyst B. The near-infrared fluorescent probe is combined with a bridging A beta inhibitor containing alkane chains through esterification reaction, wherein the near-infrared fluorescent characteristic is different from biological tissue autofluorescence signals, and the near-infrared fluorescent probe effectively identifies and combines a polypeptide region mutation site FF occurring in early stage of Alzheimer's disease to present fluorescence, and the near-infrared fluorescent probe is near redThe external fluorescent label contains an A beta inhibitor of an alkane chain connecting bridge, and then the synergistic effect enables the near-infrared fluorescent probe to cross a blood brain barrier and reach a central nervous system, so that the integration of early AD diagnosis and treatment can be realized. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113318116-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113318116-B |
| priorityDate | 2021-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.