| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46effc7a9bbc04aba2ca96ec1574f8d2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6901
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 |
| filingDate |
2021-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e32a184fdf1d7b018ec7298ae3910e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31fb81b5a30ca3b795942b4e488f99ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17186b3c4b05681c8cbaa6d316323a97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79c1a92440ed6ff6399c49bbb6111b93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70c3c0ceb13793358915577c4815061b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bda7aff893fb717d349dd42097d4507
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c549f37ef1345f2589dff9a5101c2a47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_553e37418e7e71e9a5c2c7d6b1ca8a39 |
| publicationDate |
2021-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113546056-A |
| titleOfInvention |
Preparation method and application of biomimetic nano-protective agent for detoxification of cardiac and systemic toxicity of doxorubicin |
| abstract |
The invention discloses a preparation method and application of a biomimetic nano-protective agent for detoxifying cardiac and systemic toxicity of doxorubicin. The preparation method comprises the following steps: obtaining DNA and protamine Protamine and mixing to prepare DNA nanoparticles; The functional group polyethylene glycol DSPE-PEG2000-MAL was reacted with PCM/KALA to prepare DSPE-PEG2000-PCM/KALA; DSPE-PEG2000-PCM/KALA was inserted into the surface of erythrocyte membrane RBCM to prepare PCM/KALA-RBCM; RBCM- DNA⪻@RBCM‑PCM/KALA biomimetic nanoprotective agent was prepared by mixing PCM/KALA and DNA⪻ nanoparticles. And the radioactive nanoprotective agent prepared above was applied in the interpretation of doxorubicin. The present invention can overcome the problem of leaving damage to the myocardium and/or the liver in the process of cancer treatment in the prior art, and can reduce the physical burden of the patient. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023274105-A1 |
| priorityDate |
2021-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |