Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_116c851e729089df9a427027272fa290 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa8aac9dfa2ae1357007208f2963a275 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-507 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
filingDate |
2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_084237af8e2bb21ff73ef90dbfea6341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f74307c4b2162aae5008c26430fa0e6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61a3dd61030fe234cf411779c1ae2799 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf8c71e24367abfef15fbd4f96b8665e |
publicationDate |
2021-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-113544287-A |
titleOfInvention |
pks island positive escherichia coli as marker for negative response to anti-PD 1 therapy in colorectal cancer |
abstract |
A method of predicting resistance to anti-PD 1 therapy in a subject suffering from cancer is provided, comprising the steps of a) determining the presence of islands of bacterial pks from a biological sample from the subject, in particular a stool or colon biopsy sample from the subject, b) predicting from the results of step a) that the subject is likely to be resistant to anti-PD 1 therapy. Also provided are methods of treating cancer in a subject by assessing the presence or absence of bacterial pks islands in a biological sample from the subject, particularly a stool or colon biopsy sample from the subject, and administering an anti-cancer therapy to the subject. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114344463-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114344463-B |
priorityDate |
2018-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |