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filingDate 2019-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee9682e1ce9f52bca72ec8a63dba7635
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publicationDate 2021-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113544268-A
titleOfInvention Human alpha-galactosidase variant
abstract The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. This engineered human alpha-galactosidase polypeptide has been optimized to provide increased thermostability, serum stability, increased cellular uptake, stability under acidic (pH<4) and alkaline (pH>7) conditions properties, reduced immunogenicity, and improved removal of spherical triacylceramides from cells. The present invention also relates to the use of a composition comprising the engineered human alpha-galactosidase polypeptide for therapeutic purposes.
priorityDate 2018-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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