abstract |
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. This engineered human alpha-galactosidase polypeptide has been optimized to provide increased thermostability, serum stability, increased cellular uptake, stability under acidic (pH<4) and alkaline (pH>7) conditions properties, reduced immunogenicity, and improved removal of spherical triacylceramides from cells. The present invention also relates to the use of a composition comprising the engineered human alpha-galactosidase polypeptide for therapeutic purposes. |