| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_87443969ebad9a1e5d6b409c2a9e8055 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
| filingDate |
2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bc244a51c38924829913752dfbe520c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce9561228cebd85e2e215226f85e62d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2f20d87e12ba9f4054d5f357a4f0db2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc720920939fe58a02b0c3ad7dd0c726 |
| publicationDate |
2021-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113528516-A |
| titleOfInvention |
Nucleic acid, pharmaceutical composition containing nucleic acid, siRNA conjugate, preparation method and application |
| abstract |
The present disclosure provides an siRNA for inhibiting angiotensin converting enzyme 2(ACE2) gene expression, pharmaceutical compositions and conjugates containing the siRNA. The siRNA comprises a sense strand and an antisense strand, wherein each nucleotide in the siRNA is a modified or unmodified nucleotide independently, the sense strand comprises a nucleotide sequence I, the nucleotide sequence I is equal to the nucleotide sequence shown in SEQ ID NO. 1 in length and has NO more than 3 nucleotide differences, and the antisense strand comprises a nucleotide sequence II, the nucleotide sequence II is equal to the nucleotide sequence shown in SEQ ID NO. 2 in length and has NO more than 3 nucleotide differences. The siRNA and the pharmaceutical composition and conjugate thereof provided by the disclosure can effectively treat and/or prevent novel coronavirus diseases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4180527-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114540384-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114569737-A |
| priorityDate |
2020-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |