http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113528433-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1798f5d21497d0941c11d9220164edfa |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2509-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-922 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-345 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-735 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0775 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-99 |
| filingDate | 2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d4b17aa83f21e3b9eb45973236b461f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8772939b71cf2121dff37d1c2beb83de |
| publicationDate | 2021-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113528433-A |
| titleOfInvention | A kind of umbilical cord mesenchymal stem cell exosome based on oxygen concentration gradient and its preparation method and application |
| abstract | The invention discloses an umbilical cord mesenchymal stem cell exosome based on an oxygen concentration gradient and a preparation method and application thereof. The present invention provides a method for preparing umbilical cord mesenchymal stem cell exosomes, comprising: culturing the umbilical cord mesenchymal stem cells under a series of concentration gradients from low to high oxygen concentration; collecting the culture supernatant, and separating and purifying to obtain Umbilical cord mesenchymal stem cell exosomes. Based on the oxygen concentration gradient culture technology, the invention stimulates the proliferation ability of umbilical cord mesenchymal stem cells and the potential of stress secretion of functional exosomes to the limit, and separates the supernatant stock solution rich in stem cell exosomes through centrifugal concentration and nanomembrane filtration. Retain the nutrients and active factors that promote cell growth in the supernatant of stem cell culture to the maximum extent, remove other macromolecular proteins, cell debris and other difficult-to-absorb components, and add asiaticoside, hyaluronic acid, etc., which have anti-inflammatory and moisturizing effects, with multiple repair care Efficacy, improve the microenvironment of stretch mark repair. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112007049-A |
| priorityDate | 2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.