http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113527287-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D457-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D457-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2021-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2023-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2023-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113527287-B |
| titleOfInvention | Synthesis method and application of nicergoline |
| abstract | The invention belongs to the field of medicine synthesis and discloses a synthesis method and application of nicergoline. The synthesis method provided by the present invention is that compound 1 and compound 2 are subjected to esterification reaction under the condition of concentrated sulfuric acid catalysis, and methylation reaction is carried out in an alkaline environment through methyl iodide, and after the reaction is finished, the nitric acid is obtained. Ergoline. The synthetic method of Nicergoline provided by the present invention simplifies technical process, reduces the requirement to reaction environment, improves reaction yield, saves industrial production cost; The present invention is applicable to the synthetic of Nicergoline, synthesized Nicergoline for the preparation of Nicergoline for injection. |
| priorityDate | 2021-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.