http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113527262-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2021-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113527262-B |
| titleOfInvention | A kind of purification method of delafloxacin and meglumine salt thereof |
| abstract | The invention provides a preparation process of delafloxacin and meglumine thereof, particularly a refining process of delafloxacin meglumine. The intermediate product DLSX07 is added to a reaction kettle at room temperature, ethyl acetate is added, and an ice bath is performed. Use a Branson digital ultrasonic generator to sonicate at 20% amplitude for 1 minute, then sonicate for 30 s again, until the solution is turbid, add concentrated sulfuric acid and NCS dropwise, stir and react at room temperature, add 4% KOH solution, and heat to reflux. React at 40-50°C for 3 hours, cool and slowly add distilled water, stand for 5 hours, filter with suction, vacuum-dry the filter cake to obtain a pale yellow powder, which is detected by LC-MS/MS as delafloxacin, add distilled water, and mix with meglumine Delafloxacin meglumine salt is obtained; by optimizing the preparation process, the invention reduces the use of organic solvents, shortens the reaction time, and in addition, the ice bath and the addition of interface carrier materials help to improve the yield. |
| priorityDate | 2021-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.