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filingDate 2021-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_032e928c40cb2a3ecaf0eadb33292169
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publicationDate 2021-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113527199-A
titleOfInvention A kind of preparation method of chloroquinado
abstract The invention provides a kind of preparation method of chloroquinado, described preparation method comprises: under the condition that catalyst Lewis acid exists, contains material I of 8-hydroxyl-2-methylquinoline and hydantoin, reaction I , to obtain the chloroquinaldol. The method uses dichlorohydantoin instead of chlorine as the reaction raw material, has good selectivity, few by-products, strong reaction operability, no need for shielding from light and gas protection, improves the mass yield, and has a purity of more than 99.00%, ensuring that chloroquinadol is the quality of. In the reaction process of the invention, the generation of waste liquid is reduced, the pollution to the environment is avoided to the maximum extent, the cost is saved, and the quality is improved, and it is a green and environmentally friendly process suitable for industrial production.
priorityDate 2021-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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