| abstract |
The invention discloses an asymmetric polysulfide compound represented by formula (1), formula (2), formula (3) and formula (4) and a synthesis method thereof, wherein the method is represented by formula (6), formula (7), compounds represented by formula (8) and formula (9) and disulfide reagent (5) are reaction raw materials, and under the action of a catalyst, react to obtain the asymmetric polysulfide compound. The reaction condition of the invention is mild, the raw materials are cheap and easy to obtain, the reaction operation is simple, and the yield is high; the reaction substrate is easy to prepare; the reaction of the invention can be used to construct novel polysulfide compounds. The invention also proposes the application of the asymmetric polysulfide compound in small molecule drug conjugates and polypeptide conjugates. |