http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113521281-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0038 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5026 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5031 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 |
| filingDate | 2021-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113521281-B |
| titleOfInvention | Gold microspheres with photothermal photodynamic radiation sensitization tumor treatment liquid and preparation method thereof |
| abstract | The invention discloses a liquid metal microsphere with the synergistic effect of photothermal, photodynamic and radiosensitization modes for treating tumors and a preparation method thereof. First, use esterification to link metronidazole MN to polyethylene glycol-polyacrylic acid PEG-PAA copolymer chain to prepare radiosensitizing copolymer PEG-PAA-MN; then use Michael addition reaction to prepare tumor-targeting Copolymer RGD-PEG-PAA-MN; the gallium-based liquid metal was broken into nano-microspheres (LM) by ultrasonic method, and then the targeted copolymer RGD-PEG-PAA-MN was electrostatically coated on the surface of the LM to prepare a liquid Metal nanocomposite microspheres. The method has the advantages of simple process, mild reaction conditions and easy operation; the prepared product has the functions of photothermal, composite photodynamics, and low-intensity radiosensitization under hypoxia for synergistic tumor treatment, and also has multiple tumor targeting properties and good biological properties. Capacitance, in vivo degradability, tumor hypoxia response and acidity response properties. |
| priorityDate | 2021-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.