| abstract |
The invention discloses a 3D printed tumor vaccine composition and a preparation method and application thereof. The tumor vaccine composition of the present invention is to prepare a tumor antigen or vaccine preparation and a biosafety macromolecular material into a 3D printing ink, and through 3D printing, a tumor vaccine composition with a porous structure is prepared; wherein, the porous structure is in the tumor Several pores with a pore size of 1-10 μm are arranged on the surface and inside of the vaccine composition. The tumor vaccine of the invention has good biosafety and biocompatibility, simple preparation process, and easy mass production, storage and use. The invention also discloses the anti-tumor immune efficacy of the tumor vaccine based on the 3D printing technology. After being combined with the immune checkpoint inhibitory therapy, the immune cell infiltration in the tumor tissue can be significantly improved, and the tumor can be effectively prevented and treated. |