http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113512090-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50860d756b3be339e0196137f4b667fd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 |
| filingDate | 2021-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d06ff1571903d4f73f8393c5b613f72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a20efc5b1e85dc658f3d2ddf61825a00 |
| publicationDate | 2021-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113512090-A |
| titleOfInvention | A kind of granzyme B binding compound and its precursor compound and use |
| abstract | The present invention provides compounds of general formula (I)-(IV), wherein general formula (I)-(II) is a precursor compound of the complex of general formula (III)-(IV), and general formula (III) of the present invention The metal complexes can be used for PET or SPECT imaging methods to determine the efficacy of immunotherapy, providing a new method for evaluating the efficacy of immunotherapy. Based on the granzyme B inhibitor IEPD-CHO, the present invention designs and synthesizes a new compound and radioactive metal complex that specifically targets granzyme B, which can qualitatively and quantitatively reflect the direct biological marker of granzyme B in immunotherapy. expression and activity, thus directly reflecting the immune efficacy. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023087871-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114028590-A |
| priorityDate | 2021-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 125.