| abstract |
The invention relates to substituted quinazoline-4-ketone compounds, a preparation method and application thereof, belonging to the chemical industryThe field of medicine and pharmacology. The invention provides a compound shown as a formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof or a solvate thereof. The invention also provides a preparation method and application of the compound. Biological experiments show that the compound has better inhibitory activity on PI 3K; meanwhile, the compound has better inhibitory activity on the proliferation of various tumor cells, and certain compounds show better antiproliferative activity than CAL-101 and IPI-145; and the compound also has better anti-inflammatory effect. |