| abstract |
The present invention provides a medicine for diagnosis, prevention and treatment of bone marrow proliferative tumor. An antibody that binds to a cut mutant CALR protein or a functional fragment thereof, and a drug for diagnosis, prevention and treatment of bone marrow proliferative tumors containing the antibody, the antibody or functional fragment thereof having a sequence corresponding to (a) The polypeptide chain consisting of the amino acid sequence shown in No. 1, or (b) the antigen-recognition site of the polypeptide chain consisting of the amino acid sequence of SEQ ID NO: 1 in which one or several amino acids have been deleted, substituted or added. |