| abstract |
The invention discloses a pyridylimidazole-substituted quinazolinone derivative, which has the structural formula as follows: and discloses a synthesis method thereof. The pyridylimidazole-substituted quinazolinone derivative can induce a high proportion of aneuploidy of tumor cells, so that the tumor cells are induced to die; the compounds do not act on a single target, so the compounds are not influenced by tumor types, show obvious proliferation inhibition activity on various cancer cells of human, and can induce the apoptosis of the cancer cells in a dose-dependent manner; more importantly, the compounds have better selectivity on tumor cells and have no obvious effect on normal cells of human under the effective concentrationHas cytotoxicity and good safety, and can be developed into a broad-spectrum anti-tumor candidate drug. |