http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113491251-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61D7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61D7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-02 |
| filingDate | 2021-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113491251-B |
| titleOfInvention | Preparation method of rat model of Parkinson's disease of kidney-yang deficiency type |
| abstract | The invention relates to a method for preparing a rat model of Parkinson's disease of kidney-yang deficiency type, and aims to solve the technical problems of the existing Parkinson's rat model, such as unstable symptoms, prone to poisoning reactions, and unfavorable practical application. The present invention adopts fatigue swimming test and co-cage experiment to first establish a kidney-yang deficiency animal model that completely follows the classic TCM theory, and then evaluates the model to screen out qualified kidney-yang-deficiency rats for the next step. PD modeling. After modeling, five aspects were evaluated: appearance observation, behavioral detection, serum α-syn content detection, HE staining analysis of substantia nigra and striatum tissue, TH positive immunohistochemical detection of substantia nigra and striatum tissue; In addition to observing the shape, it is also necessary to pass any of the other three tests, that is, the modeling is successful. By simulating the internal cause of Parkinson's disease, the present invention more truly reproduces the symptoms of kidney yang deficiency, and provides a real, stable and reliable simulation basis for the establishment of the PD model in the next step. |
| priorityDate | 2021-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.