http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113481292-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_217f2be73fd6be0be36dd55803d3bec5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate | 2017-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db1d9a6300b1c1e2b77d0a10e61484b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_526845287ee440b67cf71bcb3ba37213 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90a96f3c36fdddc1677c40b6209d88a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d44573b03a87552e424df7c6812c8416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ac75d2d7b82a9ea2a3988684fb91e23 |
| publicationDate | 2021-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113481292-A |
| titleOfInvention | Use of 11β-HSD2 and epigenetic markers as early markers of articular chondrodysplasia and osteoarthritis susceptibility |
| abstract | The invention discloses the use of 11β-HSD2 and its epigenetic markers as early markers of articular cartilage dysplasia and osteoarthritis susceptibility. The results showed that compared with the normal control group, the histone acetylation and expression level of the 11β-HSD2 promoter region in the umbilical cord mesenchymal stem cells or the whole umbilical cord of neonates with intrauterine growth retardation (IUGR) decreased; Mesenchymal stem cells have lower chondrogenic differentiation capacity, and are more likely to exhibit chondrocyte degeneration similar to osteoarthritis under the action of high concentrations of glucocorticoids. Therefore, by detecting the expression and epigenetic level of the umbilical cord 11β-HSD2 gene, the subjects' chondrodysplasia and the risk of developing osteoarthritis in adulthood were determined. It provides a research basis for the early warning technology of articular chondrodysplasia and fetal-derived adult osteoarthritis, and also provides a new idea for the comprehensive prevention and treatment of fetal-derived adult osteoarthritis. |
| priorityDate | 2017-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.